Beschneidung und HIV

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Dieser Artikel diskutiert die Beziehung zwischen männlicher Beschneidung und HIV-Infektion. Für eine Diskussion über Beschneidung und andere sexuell übertragbare Infektionen siehe Beschneidung und sexuell übertragbare Krankheiten.

Kürzlich wurde die Beschneidung stark als Methode zur Vorbeugung von HIV beworben. Die Weltgesundheitsorganisation (WHO), die heute als korrupt bekannt ist, hat 2007 die männliche Beschneidung als eine Form der HIV-Prävention hastig unterstützt, basierend auf drei Studien (2005) & (2007) durchgeführt in Afrika (Kenia, Südafrika und Uganda), die behaupten, von der männlichen Beschneidung werde angenommen, "das Risiko einer HIV-Übertragung um 60% zu reduzieren".[1] Diese Billigung hat zur Einrichtung von „Massenbeschneidungskampagnen“ geführt, die darauf abzielen, die Mehrheit der afrikanischen Männer in einigen wenigen Ländern zu beschneiden,[2] und zur Förderung der männlichen Beschneidung als HIV-Präventionsmethode durch die Zentren für Seuchenkontrolle.[3][4][5]

Inhaltsverzeichnis

Ursprung der Beschneidung-/HIV-Hypothese

Die Idee, dass Beschneidung die Übertragung von HIV verhindere, wurde von Valiere Alcena erfunden, lange bevor es irgendwelche "Forschungen" gab, um die Behauptung zu untermauern.[6] 1986 übernahm der kalifornische Urologe Aaron J. Fink (1926-1994) diese Idee[7] und förderte sie vehement,[8] ohne jeglichen Beweis.

1986 schickte Fink einen Brief mit dem Titel „A possible Explanation for Heterosexual Male Infection with AIDS“ an das „New England Journal of Medicine“, in dem er argumentierte, dass die harte und zähe Eichel des beschnittenen Mannes einer Infektion widerstehen würde, während die weiche und empfindliche Vorhaut und Eichel-Schleimhaut des intakten Mannes Eintrittspforten seien.[9] Fink schlug in seinem Brief vor: „Ich vermute, dass Männer in den USA, die im Vergleich zu denen in Afrika und anderswo weniger AIDS hatten, von der hohen Rate an Neugeborenenbeschneidungen in den USA profitiert haben“, ungeachtet der Tatsache, dass die USA eine der höchsten Beschneidungsraten und trotzdem eine der höchsten HIV-Raten in der westlichen (industrialisierten) Welt haben (verglichen mit europäischen Ländern, Kanada und Australien).[10]

Finks Vorschlag erschien in den Medien in den USA und Kanada. Von einem Reporter von United Press nach seiner Annahme befragt, antwortete Fink: "Das ist nichts, was ich beweisen kann."[11] Dies hinderte andere Ärzte nicht daran, "Forschung" durchzuführen, was zu einem stetigen Strom von weit verbreiteten Artikeln führte, in denen argumentiert wurde, dass beschnittene Männer weniger wahrscheinlich an HIV erkranken - mit dem Ergebnis, dass die Prävention von HIV-Infektionen jetzt sogar die Krebsprävention als beliebteste Behauptung der Beschneidungsbefürworter übertraf.

”Finks eigene Worte
Das ist nichts, was ich beweisen kann.
– Aaron J. Fink (Marked in Your Flesh, S. 206-208.)

Fink gab die Beschneidung-/HIV-Kontroverse 1991 auf und starb 1994. Trotzdem hinterließ er ein unauslöschliches Vermächtnis; die Beschneidung-/HIV-Hypothese wird weiterhin von Forschern und Wissenschaftlern unterstützt, die seine Behauptungen übernehmen und darauf basierende Studien schreiben. Auch die Kampagne, einen kausalen Zusammenhang zwischen einer HIV-Infektion und dem Vorhandensein der Vorhaut herzustellen, dauert bis heute an.

Frühe Forschung

(Dieser Artikel wurde noch nicht aus dem Englischen übersetzt oder enthält noch englische Textpassagen. Bitte beziehe dich vorerst auf die Informationen im englischen Artikel. Klicke dazu in der IntactiWiki-Navigation im Abschnitt "In anderen Sprachen" auf "English".)

Hrdy (1987) identified numerous African cultural practices other than circumcision or non-circumcision that would contribute to the spread of HIV infection. Such factors include:

  • Female circumcision and infibulation.
  • Promiscuity.
  • Homosexuality and anal intercourse.
  • Practices resulting in exposure to blood.
  • Practices involving the use of shared instruments.
  • Contact with non-human primates.[12]

Carael et al. (1988) studied HIV transmission among heterosexual couples in Central Africa. No difference was found between couples in which the male was circumcised and in which the male was intact.[13]

de Vincenzi & Mertens (1994) reviewed the literature regarding the alleged role of the foreskin in HIV transmission. They concluded:

The potential public-health benefits of male circumcision have been greatly discussed in the past 50 years, often in a passionate and emotional manner. However, relatively few studies have been carried out and those that have, present conflicting results. The major criticism of most of the studies preformed to date is the lack of attention given to potential confounding factors, which could be related to both circumcision status and risk of sexually transmitted infections, such as sexual behaviour or differences in hygienic practices, or differential use of specific health facilities. As Poland [48] noted, "We must remember that circumcision is not performed randomly."

Therefore, further efforts are still required to quantify the relative risk associated with the lack of male circumcision. Some of this can be achieved by using observational designs which better address the limitations discussed above. Laboratory and primate research might also continue to provide useful information.

As the safety, expected benefits, feasibility and acceptability of mass circumcision are all questionable, neither public-health interventions nor intervention studies appear to be defensible options before there is stronger evidence from observational studies in different settings that show lack of male circumcision may be a genuinely independent risk factor for the transmission of HIV.[14]

Darby (2002) examined the claims that circumcision is preventive of infection with HIV. He tabulated the prevalence of circumcision and HIV infection in various nations. He found no connection between the prevalence of circumcision and HIV infection. Darby also compared the nineteenth century British attempts to control syphilis (then a dreaded and incurable disease) with male circumcision, which was equally unsuccessful.[15]

Thomas et al. (2004) studied the incidence of HIV in circumcision and intact men in a United States Navy population. A slightly higher incidence of HIV infection was found in circumcised men (84.9%) as compared with intact men (81.8%). The authors concluded:

Although there may be other medical or cultural reasons for male circumcision, it is not associated with HIV or STI prevention in this U.S. military population.[16]

Störfaktoren

Widerlegte Ad-hoc-Hypothesen

Various hypotheses have been suggested in regards to the mechanism whereby circumcision prevents the tarnsmission of HIV. They have all been disproven, however, and all of the "studies" attempting to establish a causal link between circumcion and HIV transmission remain unsubstantiated by a working hypothesis.

Keratinisierungshypothese

Perhaps the oldest hypothesis on the mechanism whereby circumcision prevents the transmission of HIV is the theory that suggests that the keratinized surface of the penis in circumcised male resists infection, while the mucosa of the glans and inner of the intact male are ports of entry, which was purported by Aaron J. Fink.

Recent studies, however, disprove this hypothesis. One study found that there is "no difference between the keratinization of the inner and outer aspects of the adult male foreskin," and that "keratin layers alone were unlikely to explain why uncircumcised men are at higher risk for HIV infection."[17] Another study found that "no difference can be clearly visualized between the inner and outer foreskin."

Langerhans-Zellen-Hypothese

Recent circumcision studies in Africa were conducted under the hypothesis that the Langerhans cells were the prime port of entry for the HIV virus. According to the hypothesis, circumcision was supposed to prevent HIV transmission by removing the Langerhans cells found in the inner mucosal lining of the foreskin.

deWitte found that not only are Langerhans cells found all over the body and that their complete removal is virtually impossible, but furthermore, deWitte found that Langerhans cells that are present in the foreskin produce Langerin, a substance that has been proven to kill the HIV virus on contact, acting as a natural barrier to HIV-1 transmission by Langerhans cells.[18]

Hypothese der bakteriellen Umgebung

This hypothesis attempts to identify the change in bacterial environment that results in the penis as a result of circumcision, as the mechanism whereby circumcision reduces the spread of HIV transmission. A desperate ad-hoc hypothesis, the explanation is rather farfetched. The argument is that the change in bacterial environment after circumcision makes it difficult for bacteria that cause diseases to live; there are less chances for penile inflammation, a condition that facilitates the transmission of viruses. The chances for penile inflammation are reduced, thereby reducing the chances of sexually transmitted viruses, such as HIV.[19]

Presenting this hypothesis presents a two-fold problem. First, it presents an irrelevant conclusion; the randomized control trials were measuring frequency in HIV transmission, not for frequency in penile bacterial inflamation, and whether said inflamation facilitated sexually transmitted HIV. And secondly, circumcision advocates give themselves the new burden of proving the newly introduced hypothesis, that change in bacterial infection does indeed result in a significant reduction of HIV transmission. A new study is needed to measure HIV transmission in men who have been circumcised, intact men with constant penile inflamations, and intact men who don't suffer constant penile inflammation. Unless the randomized controlled studies were limited to only intact men who suffered constant penile inflammation.

Die immunologische Funktion der Vorhaut

The foreskin's inner fold and the glans of the penis are comprised of mucous membrane tissue. These are also present in your eyes, mouth, and all other bodily orifices including the female genitals. These are the first line of immunological defense for the body's orifices. These mucous membranes perform many immunological and hygienic functions.

Certain components such as Langerhans cells,[20] plasma cells,[21] apocrine glands,[22] and sebaceous glands,[23][24][25][26], collectively secrete emollient lubricants.[27] Apocrine glands perform a crucial function by secreting enzymes such as lysosomal enzymes, cathepsin B, chymotrypsin, and neutrophil elastase.[28]

There is also some research to suggest that lysozyme may protect against HIV infection.[29] [30]

Apocrine glands also produce cytokine,[31] which is a very important non-antibody protein that generates immune response when in contact with specific agents. Plasma cells which increase in number in response to pathogens levels, secrete immunoglobulin.[21] It is also very important to note that Langerhans cells that are present in the foreskin produce Langerin, a substance that has been proven to kill human immunodeficency virus (HIV) on contact.[32]

All of these function to sequester and “digest” foreign pathogens. All these substances play an important role in protecting the penis from viral and bacterial pathogens. The immunological functions of the human prepuce have been extensively documented by respected researchers for quite some time.[30]

Circumcision destroys the natural immunological protections of the foreskin and results in increased risk of contracting infection.

Afrikanische RCTs

Strong bias exists in the RCTs.[33][34][35][36][37] "These trials, designed to detect a minimum 50 percent reduction in HIV risk, should provide definitive evidence regarding the efficacy and safety of MC within three to five years."[38] By designing a trial to "detect" a minimum 50 percent reduction risk in HIV, these researchers might have artificially created the clinical setting to observe the effect they were looking to discover.

Boyle & Hill (2011) have shown these RCTs to be have significant methodological flaws and statistical errors that render their claims invalid. Although a 60 percent relative reduction in HIV was claimed, the absolute reduction was a statistically insignificant 1.3 percent.[39]

Concerns about the three randomized controlled clinical trials (RCCTs) in Africa (in South Africa, Uganda, and Kenya)[40][41][42]:

  • The three RCTs were terminated early because results had reached a signifıcent level showing reduced HIV infections in experimental compared with control groups; however, it was too soon to gauge long-term effectiveness.
  • The results have no relevance for women or for men who have sex with men.
  • Far more participants were lost to follow-up than were reported to have contracted HIV.
  • A substantial number of participants appeared to have contracted HIV from nonsexual sources: 23 of the 69 infections reported in the South African trial and 16 of the 67 in the Ugandan study.[43]
  • Participants received continuous counseling, free condoms, and monitoring for infection, which was unlikely in real-world campaigns.
  • The sanitary conditions of the surgeries would be diffıcult to replicate on a mass scale in many parts of Africa where HIV infection rates and prevalence are highest.[44][45]
  • Follow-up of any of these RCCTs is impossible. Study participants agreed to be circumcised when joining the study and were randomized into “circumcise now” and “circumcise later” groups.[46]

Daten aus der realen Welt

Länder in Afrika

According to demographic health studies performed in other countries in Africa, HIV transmission was prevalent in circumcised men in at least 6 different countries:

Kamerun

In Cameroon, where 91% of the male population is circumcised, the ratio of circumcised men vs. intact men who contracted HIV was 4.1 vs. 1.1. [47]

Ghana

In Ghana, the ratio is 1.6 vs 1.4 (95.3% circumcised). "...the vast majority of Ghanaian men (95 percent) are circumcised... There is little difference in the HIV prevalence by circumcision status..."[48]

Lesotho

In Lesotho, the ratio is 22.8 vs 15.2 (23% circumcised). "The relationship between male circumcision and HIV levels in Lesotho does not conform to the expected pattern of higher rates among uncircumcised men than circumcised men. The HIV rate is in fact substantially higher among circumcised men (23 percent) than among men who are not circumcised (15 percent). Moreover, the pattern of higher infection rates among circumcised men compared with uncircumcised men is virtually uniform across the various subgroups for which results are shown in thetable. This finding could be explained by the Lesotho custom to conduct male circumcision later in life, when the individuals have already been exposed to the risk of HIV infection. (Additional analysis is necessary to better understand the unexpected pattern in Table 12.9.)"[49]

An interesting defense of male circumcision, given the fact that the latest "studies," if they can even be called that, observed HIV transmission in men circumcised as adults. Then again, this demographic health survey was conducted in 2004, BEFORE the newer "studies" in 2006. None the less, the unproven assertion that "circumcision is only effective in reducing the risk of HIV when done in infancy" persists in some circles.

Malawi

DHS 2004 - 13.2 vs 9.5 (20% circumcised)

"The relationship between HIV prevalence and circumcision status is not in the expected

direction. In Malawi, circumcised men have a slightly higher HIV infection rate than men who were not circumcised (13 percent compared with 10 percent). In Malawi, the majority of men are not circumcised (80 percent).[50]

...where one would expect HIV to be the most rampant.

Ruanda

DHS 2005 - 3.8 vs 2.1 [51]

Südafrika

Rosenberg et al. (2018) report that circumcised men in South Africa are more likely to be HIV infected than intact men.[52]

Swasiland

DHS 2006-2007 - 22 vs 20

"As Table 14.10 shows, the relationship between HIV prevalence and circumcision status is not in the expected direction. Circumcised men have a slightly higher HIV infection rate than men who are not circumcised (22 percent compared with 20 percent).[53]

Sambia

The prevalence of HIV infection among men aged 15-29 has not decreased despite several campaigns to perform male circumcision.

Garenne & Matthews (2019) report:

In a multivariate analysis, based on the 2013 DHS survey, circumcised men were found to have the same level of infection as uncircumcised men, after controlling for age, sexual behaviour and socioeconomic status. Lastly, circumcised men tended to have somewhat riskier sexual behaviour than uncircumcised men. This study, based on large representative samples of the Zambian population, questions the current strategy of mass circumcision campaigns in southern and eastern Africa.[54]

Malaysia

According to Malaysian AIDS Council vice-president Datuk Zaman Khan, more than 70% of the 87,710 HIV/AIDS sufferers in the country are Muslims. In Malaysia, most, if not all Muslim men are circumcised, whereas circumcision is uncommon in the non-Muslim community. 60% of the Malaysian population is Muslim, which means that HIV is spreading in the community where most men are circumcised at an even faster rate, than in the community where most men are intact.[55]

Interestingly enough, Malaysia is home to the TARA KLamp, a controversial circumcision device being marketed in KwaZulu Natal, Africa in the name of HIV prevention.

Phillipinen

Tuli or male circumcision, a nearly compulsory cultural practice in the Philippine Islands, causes 93 percent of Filipino males to be circumcised. In the 2010 Global AIDS report released by UNAIDS in late November, the Philippines was one of seven nations in the world which reported over 25 percent in new HIV infections between 2001 and 2009, whereas other countries have either stabilized or shown significant declines in the rate of new infections. Among all countries in Asia, only the Philippines and Bangladesh are reporting increases in HIV cases, with others either stable or decreasing. [56]

The statistics suggest that removal of the protective foreskin by circumcision increases the risk of contracting HIV infection.

Israel

Despite circumcision being near-universal, HIV is an increasing problem in Israel.[57][58][59][60]

USA

In America, the majority of the male population is circumcised, approximately 62%,[61] while in most countries in Europe, circumcision is uncommon. One would expect for there to be a lower transmission rates in the United States, and for HIV to be rampant in Europe; HIV transmission rates are in fact higher in the United States, where most men are circumcised, than in various countries in Europe, where most men are intact.[62]

A common explanation given for this difference is the fact that sex education and instruction in the proper use of condoms is better executed in Europe than in the United States, where sex education is poor.

However, it is precisely these reasons given, that sex education and condoms aren't catching on in Africa, why circumcision advocates say "mass circumcision campaigns" should be promoted in Africa. What failed in the United States is somehow supposed to work miracles in Africa.

Studien mit gegensätzlichen Schlussfolgerungen

According to USAID, there appears no clear pattern of association between male circumcision and HIV prevalence—in 8 of 18 countries with data, HIV prevalence is lower among circumcised men, while in the remaining 10 countries it is higher.[63]

"Conclusions: We find a protective effect of circumcision in only one of the eight countries for which there are nationally-representative HIV seroprevalence data. The results are important in considering the development of circumcision-focused interventions within AIDS prevention programs."[64]

Results: ...No consistent relationship between male circumcision and HIV risk was observed in most countries."[65]

Findings

Male circumcision has been found not to decrease the risk of HIV and may in fact increase the risk of male to female transmission[66][67][68][69][70]

FolgestudienFolgestudien

Using a population-based survey, Westercamp et al. (2010) examined the behaviors, beliefs, and HIV/HSV-2 serostatus of men and women in the traditionally non-circumcising community of Kisumu, Kenya prior to establishment of voluntary medical male circumcision services. A total of 749 men and 906 women participated. Circumcision status was not associated with HIV/HSV-2 infection nor increased high risk sexual behaviors. In males, preference for being or becoming circumcised was associated with inconsistent condom use and increased lifetime number of sexual partners. Preference for circumcision was increased with the belief that circumcised men are less likely to become infected with HIV.[71]

Realität

An analysis of HIV prevalence compared to circumcision status in sub-Saharan Africa concluded that male circumcision is not associated with reduced HIV prevalence.[72] Another study on circumcision prevalence compared to HIV in the general South African population concluded: “Circumcision had no protective effect on HIV transmission.”[73] When commercial sex worker patterns are controlled, male circumcision is not signifıcantly associated with lower HIV prevalence.[74] Mathematical impact modeling of circumcision, antiretroviral therapy (ART), and condom use for South Africa concluded: “Male circumcision was found to have considerably lower impact than condom use or anti-retroviral therapy on HIV infection rates and death rates.”[75] Both the U.S. and sub-Saharan Africa have relatively high incidence rates of HIV infection, considering that about 75% of U.S. men and about 70% of sub-Saharan African men are circumcised—higher percentages than in most other regions or countries with lower prevalence of HIV.[76]

There is no clear pattern of association between male circumcision and HIV prevalence. In 10 out of 18 countries, HIV prevalence is higher amongst circumcised men.[77] Furthermore, HIV prevalence was found to be higher amongst circumcised males and females for virgins and adolescents in Kenya, Lesotho, and Tanzania.[78]

David Gisselquist, Ph.D.[a 1], who has studied health care practices in sub-Saharan Africa, finds that much of health care, especially injection practices, in Africa is non-sterile, and is likely the cause of the high incidence of HIV infection. He notes that the consensus to make sex the primary cause of infection was determined in the 1980s and is likely to be inaccurate, because it does not give sufficient weight to medical transmission of HIV infection.[79] Gisselquist et al. argue strongly that statistical evidence indicates that 5/6s of the HIV infection in Africa is non-sexual.[80][81] Male circumcision has been proposed to reduce the incidence of sexual transmission of HIV. In reality, it actually increases the sexual transmission of HIV. Even if it did work, it would be ineffective against non-sexual transmission by unsafe health care. Furthermore, non-sterile health care could mean that the circumcision operation could transmit the HIV infection to the patient.[82]

Probleme durch Förderung der Beschneidung als HIV-Präventionspolitik

The fact that the World Health Organization is corrupt is now well-established:

Circumcision advocates use the latest African studies and WHO's endorsement based on them as proof "beyond reasonable doubt" that circumcision "reduces the risk of HIV." However, there are problems with the WHO's endorsement, as the studies on which it is based on suffer various flaws and confounding factors that bring their credibility in to question, many of which will be discussed in this article.

On their website, the WHO acknowledges that, "[m]ale circumcision provides only partial protection," and that it should be part of a "comprehensive HIV prevention package" that includes HIV testing and counseling services, treatment for STD infections, the promotion of safer sex practices and the provision of condoms and the promotion of their correct and consistent use.

Van Howe & Boyle (2018) pointed out numerous reasons that one should doubt the published results of the randomised clinical trials (RCTs)[83]

George C. Denniston, M.D.[a 2], M.P.H.[a 3], the president of Doctors Opposing Circumcision, in a letter to Ambassador Deborah L. Birx, M.D.[a 2], M.P.H.[a 3], (2020), the head of the President’s Emergency Plan for AIDS Relief (PEPFAR) has called on PEPFAR to suspend the provision of male circumcision because it is ineffective and may increase the reception of HIV infection due to the loss of immunological protections of the foreskin, and to focus on the provision of anti-retroviral therapy and condoms.[84]

Fish et al. (2020), speaking for the VMMC Experience Project, published an article that described the PEPFAR program to circumcise African men, as racist and neo-colonialist.[85]

September 2021

September 2021 saw the publication of two huge population studies on the relationship of circumcision and HIV infection.

Mayan et al. (2021) carried out a massive empirical study of the male population of the province of Ontario, Canada (569,950 males), of whom 203,588 (35.7%) were circumcised between 1991 and 2017. The study concluded that circumcision status is not related to risk of HIV infection.[86]

Morten Frisch and Jacob Simonsen (2021) carried out a large scale empirical population study in Denmark of 855,654 males regarding the alleged value of male circumcision in preventing HIV and other sexually transmitted infections in men. They found that circumcised men have a higher rate of STI and HIV infection overall than intact men.[87]

There now is credible evidence that the massive, expensive African circumcision programs have not been effective in preventing HIV infection.

Erhöhtes Risiko für Frauen

A recent prospective study[88] showed that male circumcision offered no protection to women, and an RCCT[89] found that male circumcision actually increased the risk to women. Women also are placed at greater risk from unsafe sex practices when they, or their circumcised male partners, wrongly believe that with circumcision they are immune to HIV and therefore they choose not to use condoms.[90][91]

There are legitimate additional concerns about:

  • How male circumcision programs, or being circumcised, will influence human behavior.
  • The sidelining of women when considering male circumcision as a prevention method.
  • The tendency of both men and women to ascribe undue power to a technical fıx for what must remain a matter of human control, as in the use of condoms and other safe sex practices.[76]

Effektive Vorbeugung

Estimated per act risk for acquisition
of HIV by exposure route (US only) [92]
Exposure Route Estimated infections
per 10,000 exposures
to an infected source
Blood Transfusion 9,000[93]
Childbirth (to child) 2,500[94]
Needle-sharing injection drug use 67[95]
Percutaneous needle stick 30[96]
Receptive anal intercourse* 50[97][98]
Insertive anal intercourse* 6.5[97][98]
Receptive penile-vaginal intercourse* 10[97][98][99]
Insertive penile-vaginal intercourse* 5[97][98]
Receptive oral intercourse*§ 1[98]
Insertive oral intercourse*§ 0.5[98]
* assuming no condom use
§ source refers to oral intercourse
performed on a man

The three main transmission routes of HIV are sexual contact, exposure to infected body fluids or tissues, and from mother to fetus or child during perinatal period. It is possible to find HIV in the saliva, tears, and urine of infected individuals, but there are no recorded cases of infection by these secretions, and the risk of infection is negligible.[100] Anti-retroviral treatment (ART) of infected patients also significantly reduces their ability to transmit HIV to others, by reducing the amount of virus in their bodily fluids to undetectable levels.[101] [84]

Siehe auch

Weblinks

Abkürzungen

  1. ↑   Doctor of Philosophy [Doktor der Philosophie] (Englisch), Wikipedia (englisch). Abgerufen 16. Juni 2021.
  2. ↑ a b   Doctor of Medicine, Wikipedia (englisch). Abgerufen 14. Juni 2021.
  3. ↑ a b   Master of Public Health oder Master of Philosophy in Public Health, Wikipedia (englisch). Abgerufen 14. Juni 2021.

Einzelnachweise

  1. ↑   (2007). Male circumcision for HIV prevention [Männliche Beschneidung zur HIV-Prävention] (Englisch), Weltgesundheitsorganisation. Abgerufen 6. Mai 2011.
  2. ↑   Mazzotta, Meredith (4. März 2011)."Swaziland embarks on ambitious plan to circumcise 80 percent of men 18 to 49 this year" [Swasiland beginnt mit einem ehrgeizigen Plan, dieses Jahr 80 Prozent der Männer zwischen 18 und 49 Jahren zu beschneiden] (Englisch), Science Speaks: HIV & TB News. Abgerufen 6. Mai 2011. "The emphasis is on reaching 80 percent coverage with the Soka Uncobe campaign..."
  3. ↑   (Februar 2008). Male Circumcision and Risk for HIV Transmission and Other Health Conditions: Implications for the United States [Männliche Beschneidung und Risiko für HIV-Übertragung und andere Gesundheitszustände: Implikationen für die Vereinigten Staaten] (Englisch), CDC. Abgerufen 1. Juni 2011.
  4. ↑   (März 2007). Success Stories: Male Circumcision: A Question and Answer Session [Erfolgsgeschichten: Männliche Beschneidung: Eine Frage-und-Antwort-Sitzung] (Englisch), CDC. Abgerufen 1. Juni 2011.
  5. ↑   (9. Januar 2011). Funding. Abgerufen 1. Juni 2011.
  6. ↑   Alcena V. AIDS in Third World Countries [AIDS in Ländern der Dritten Welt] (Englisch). N Y State J Med. Oktober 2006; 8: 446. PMID. DOI. Abgerufen am 28. Mai 2020.
  7. ↑   Glick LB (2005): "This Little Operation", Jewish American Physicians and Twentieth-Century Circumcision Advocacy, in: Marked in Your Flesh. S. 206. New York, NY: Oxford University Press. Zitat: What if circumcision protected against infection with HIV.... ISBN 0-19-517674-X. Abgerufen 19. Februar 2011.
  8. ↑   Weiss HA, Quigley MA, Hayes RJ. Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis [Männliche Beschneidung und das Risiko einer HIV-Infektion in Afrika südlich der Sahara: eine systematische Überprüfung und Metaanalyse] (Englisch). AIDS. Oktober 2000; 14(15): 2361-2370. PMID. DOI.
  9. ↑   Fink AJ. A possible Explanation for Heterosexual Male Infection with AIDS [Eine mögliche Erklärung für heterosexuelle männliche Infektionen mit AIDS] (Englisch). New England Journal of Medicine. 315(18): 1167. PMID.
  10. ↑   WHO/UNAIDS (2004). A global view of HIV infection [Eine globale Sicht auf die HIV-Infektion] (Englisch), Weltgesundheitsorganisation. Abgerufen 27. Februar 2011.
  11. ↑   Glick LB (2005): "This Little Operation", Jewish American Physicians and Twentieth-Century Circumcision Advocacy, in: Marked in Your Flesh. S. 207. New York, NY: Oxford University Press. Zitat: This is nothing I can prove.. ISBN 0-19-517674-X. Abgerufen 19. Februar 2011.
  12. ↑   Hrdy DB. Cultural practices contributing to the transmission of human immunodeficiency virus in Africa. Rev Infect Dis. November 1987; 9(6): 1109-19. PMID. DOI. Abgerufen am 12. Mai 2021.
  13. ↑   Carael M, Van de Perre PH, LePage PH, Allen S, et al. Human immunodeficiency virus transmission among heterosexual couples in Central Africa. AIDS. Juni 1988; 2(3): 201-5. PMID. Abgerufen am 28. Mai 2020.
  14. ↑   de Vincenzi I, Mertens T. Male circumcision: a role in HIV prevention?. AIDS. 1994; 8(2): 153-60. PMID. Abgerufen am 29. Mai 2020.
  15. ↑   Darby R. Been There, Done That: Thoughts on the proposition that yet more circumcision can save the world from AIDS. Australian Quarterly. September 2002; 74(5): 26-35. Abgerufen am 8. Mai 2021.
  16. ↑ Thomas AG, Bakhireva LN, Brodine SK, Shaffer RA. Prevalence of male circumcision and its association with HIV and sexually transmitted infections in a U.S. Navy population. Abstract no. TuPeC4861. Presented at the XV International AIDS Conference, Bangkok, Thailand, July 11-16, 2004.
  17. ↑   Dinh MH, McRaven MD, Kelley Z, Penugonda S, Hope TJ. Keratinization of the adult male foreskin and implications for male circumcision. AIDS. 27. März 2010; 24(6): 899-906. PMID. Abgerufen am 28. Juni 2011.
    Zitat: We found no difference between the keratinization of the inner and outer aspects of the adult male foreskin. Keratin layers alone are unlikely to explain why uncircumcised men are at higher risk for HIV infection.
  18. ↑   de Witte L, Nabatov A, Pion M, Fluitsma D, de Jong MAWP, de Gruijl T, Piguet V, van Kooyk Y, Geijtenbeek TBH. Langerin is a natural barrier to HIV-1 transmission by Langerhans cells  . Nature Medicine. 4. März 2007; 13(3): 367-71. PMID. PMC. DOI. Abgerufen am 2. Juli 2020.
  19. ↑   Price LB, Liu CM, Johnson KE, Aziz M, Lau MK, Bowers J, Ravel J, Keim PS, Serwadda D, et al. The Effects of Circumcision on the Penis Microbiome. PLoS ONE. 2010; 5(1) DOI. Abgerufen am 29. Juni 2011.
    Zitat: The anoxic microenvironment of the subpreputial space may support pro-inflammatory anaerobes that can activate Langerhans cells to present HIV to CD4 cells in draining lymph nodes. Thus, the reduction in putative anaerobic bacteria after circumcision may play a role in protection from HIV and other sexually transmitted diseases.
  20. ↑   Weiss GN, Sanders M, Westbrook KC. The distribution and density of Langerhans cells in the human prepuce: site of diminished immune response?. Isr J Med Sci. Januar 1993; 29(1): 42-43. Abgerufen am 20. Oktober 2019.
  21. ↑ a b   Flower PJ, Ladds PW, Thomas AD, Watson DL. An immunopathologic study on the bovine prepuce. Vet Pathol. März 1983; 20(2): 189-201. Abgerufen am 20. Oktober 2019.
  22. ↑   Ahmed A, Jones AW. Apocrine Cystadenoma: a report of two cases occurring on the prepuce. Br J Dermatol. Dezember 1969; 81(12): 899-901. Abgerufen am 20. Oktober 2019.
  23. ↑   Hyman AB, Brownstein MH. Tyson's "glands": ectopic sebaceous glands and papillomatosis penis. Arch Dermatol. Januar 1969; 99(1): 31-36. Abgerufen am 20. Oktober 2019.
  24. ↑   Delbanco E. Über das gehäufte Auftreten von freien Talgdrüsen an der Innenfläche des Präputiums [About the increased occurrence of free sebaceous glands on the inner surface of the prepuce] (German). Monatshefte für praktische Dermatologie. 1904; 38: 536-538. Abgerufen am 20. Oktober 2019.
  25. ↑   Piccinno R, Carrel CF, Menni S, et al. sebacous glands mimicking molluscum contagiosum. Acta Derm Venerol. 1990; 70: 344-345.
  26. ↑   Krompecher S. Die Histologie der Absonderung des Smegma praeputii [Histology of allocation of a smegma praeputii] (German). Anatomischer Anzeiger. 1932; 75: 170-176.
  27. ↑   Parkash S, Jeykumar S, Subramanyan K, Chaudhuri S. Human subpreputial collection: its nature and formation. J Urol. August 1973; 110(2): 211-212. Abgerufen am 20. Oktober 2019.
  28. ↑   Frohlich E, Shamburg-Lever G, Klesses C. Immunelectron microscopic localization of cathepsin B in human apocrine glands. J Cutan Pathol. Februar 1993; 20(1): 54-60.
  29. ↑   Hill, George (7. September 2003). Summary of evidence that the foreskin and lysozyme may protect against HIV infection. Abgerufen 20. Oktober 2019.
  30. ↑ a b   Fleiss PM, Hodges FM, Van Howe RS. Immunological functions of the human prepuce. Sex Trans Infect. Oktober 1998; 74(5): 364-67. PMID. PMC. DOI. Abgerufen am 14. Januar 2022.
  31. ↑   Ahmed AA, Nordlind K, Schultzberd M, Liden S. Immunohistochemical localization of IL-1 alpha-, IL-1 beta-, IL-6- and TNF-alpha-like immunoreactivities in human apocrine glands. Arch Dermatol Res. 1995; 287(8): 764-766. Abgerufen am 20. Oktober 2019.
  32. ↑   de Witte L, Nabatov A, Pion M, et al. Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nat Med. März 2007; 13(3): 367-371. Abgerufen am 20. Oktober 2019.
  33. ↑   Green LW, et al. Male circumcision is not the HIV 'vaccine' we have been waiting for!  . Future HIV Ther. 2008; 2(3): 193–199.
  34. ↑   Montori VM, Devereaux PJ, Adhikari NKJ, et al. Randomized trials stopped early for benefit: a systematic review. JAMA. 2005; 294: 2203-2209.
  35. ↑   Ioannidis JP. Contradicted and initially stronger effects in highly cited clinical research  . JAMA. 2005; 294: 218-228.
  36. ↑   Wheatley K, Clayton D. Be skeptical about unexpected large apparent treatment effects: the case of an MRC AML12 randomization. Control Clin Trials. 2003; 24: 66-70.
  37. ↑   Slutsky AS, Lavery JV. Data safety and monitoring boards. N Engl J Med. 2004; 350: 1143-1147.
  38. ↑   Program and Policy Implications For HIV Prevention and Reproductive Health  , Beitrag: Male Circumcision: Current Epidemiological and Field Evidence, USAID. (Januar 2002). Abgerufen 29. September 2019.
    Zitat: designed to detect a minimum 50 percent reduction in HIV risk
  39. ↑   Boyle GJ, Hill G. Sub-Saharan African randomised clinical trials into male circumcision and HIV transmission: Methodological, ethical and legal concerns   [Randomisierte klinische Studien in Afrika unterhalb der Sahara zur männlichen Beschneidung und HIV-Übertragung: Methodische, ethische und rechtliche Bedenken {language=Englisch]. Thompson Reuter. Dezember 2011; 19(2): 316-34. PMID. Abgerufen am 30. Dezember 2020.
  40. ↑   Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial [Immunologische und schützende Funktion der VorhautRandomisierte, kontrollierte Interventionsstudie zur männlichen Beschneidung zur Verringerung des HIV-Infektionsrisikos: Die ANRS-1265-Studie] (Englisch). PLoS Med. 25. Oktober 2005; 2(11): e298. Abgerufen am 31. Dezember 2021.
  41. ↑   Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: A randomised controlled trial [Männliche Beschneidung zur HIV-Prävention bei jungen Männern in Kisumu, Kenia: Eine randomisierte kontrollierte Studie] (Englisch). Lancet. 24. Februar 2007; 369(9562): 643–56. PMID. DOI. Abgerufen am 31. Dezember 2021.
  42. ↑   Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: A randomised trial [Männliche Beschneidung zur HIV-Prävention bei Männern in Rakai, Uganda: Eine randomisierte Studie] (Englisch). Lancet. 24. Februar 2007; 369(9562): 657-66. PMID. DOI. Abgerufen am 31. Dezember 2021.
  43. ↑   Gisselquist D (2008): 7, in: Points to consider: responses to HIV/AIDS in Africa, Asia, and the Caribbean. London: Adonis and Abbey.
  44. ↑   Weiss HA, Quigley MA, Hayes RJ. Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. AIDS. 2000; 14: 2361–2370.
  45. ↑   Siegfried N, Muller M, Deeks J, et al. HIV and male circumcision — a systematic review with assessment of the quality of studies. Lancet Infect Dis. 2005; 5: 165–173.
  46. ↑   Slutsky AS, Lavery JV. Data safety and monitoring boards. N Engl J Med. 2004; 350: 1143-1147.
  47. ↑   Mosoko JJ, Affana GAN (2005): 16, in: Prévalence du VIH et facteurs associés. Calverton, MD, USA (Hrsg.). Ausgabe: Enquête Démographique et de Santé du Cameroun. S. 309. Cameroon: DHS. Zitat: Contrairement aux résultats trouvés dans d’autres pays, notamment le Kenya.... Abgerufen 2. Juni 2011.
  48. ↑   Marum L, Muttunga J, Munene F (Central Bureau of Statistics): 13, in: HIV Prevalence and Associated Factors. Arbeit: Kenya: Demographic and Health Survey 2003. S. 250-251. Nairobi, Kenya: Central Bureau of Statistics. Zitat: ...the vast majority of Ghanaian men (95 percent) are circumcised... There is little difference in the HIV prevalence by circumcision status....
  49. ↑   (2005) HIV Prevalence and Associated Factors. Arbeit: Lesotho Demographic and Health Survey 2004. S. 13. Calverton, Maryland: Ministry of Health and Social Welfare. Abgerufen 2. Juni 2011.
  50. ↑   Chipeta J, Schouten E, Aberle-Grasse J (2005): 12, in: HIV Prevalence and Associated Factors. Arbeit: Malawi Demographic and Health Survey 2004. S. 234. Calverton, Maryland: National Statistical Office. Abgerufen 2. Juni 2011.
  51. ↑ http://www.measuredhs.com/pubs/pdf/FR183/15Chapter15.pdf p. 10
  52. ↑   Rosenberg MS, Gómez-Olivé FX, Ronr JK, Kahn K, Bärnighausen TW. Are circumcised men safer sex partners? Findings from the HAALSI cohort in rural South Africa. PLOS ONE. 1. August 2018; 13(8): e0201445. PMID. PMC. DOI. Abgerufen am 20. Oktober 2019.
  53. ↑ http://www.measuredhs.com/pubs/pdf/FR202/FR202.pdf P. 256
  54. ↑   Garenne M, Matthews A. Voluntary medical male circumcision and HIV in Zambia: expectations and observations. J Biosoc Sci. 14. Oktober 2019; Epub ahead of print: 1-13. PMID. DOI. Abgerufen am 19. Oktober 2019.
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  56. ↑ http://globalnation.inquirer.net/news/breakingnews/view/20110102-312124/Philippines-HIVAIDS-problem-worries-UN
  57. ↑   (4. Juli 2008). Failing the AIDS Test. Abgerufen 5. Januar 2020.
  58. ↑   (9. Juli 2008). Israeli Gays Shun Condoms Despite Worrying Rise in AIDS. Abgerufen 5. Januar 2020.
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  63. ↑ http://www.measuredhs.com/pubs/pdf/CR22/CR22.pdf
  64. ↑ http://www.iasociety.org/Default.aspx?pageId=11&abstractId=2197431
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  66. ↑   Castilho, E.A., mit: Boshi-Pinto C., Guimaraes M.D.G.: Male circumcision and HIV heterosexual transmission (2002) XIV World AIDS Conference.
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  69. ↑   Changedia, S.M., mit: Gilada I.S.: Role of male circumcision in HIV transmission insignificant in Conjugal relationship (2002) XIV World AIDS Conference.
  70. ↑   (6. März 2007). Circumcision protects men from AIDS but might increase risk to women, early results suggest, International Herald Tribune.
  71. ↑   Westercamp M, Bailey RC, Bukusi EA, Montandon M, Kwena Z, et al. Male Circumcision in the General Population of Kisumu, Kenya: Beliefs about Protection, Risk Behaviors, HIV, and STIs. PLoS ONE. 2010; 5(12) DOI.
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  73. ↑   Connolly C, Simbayi LC, Shanmugam R, Nqeketo A. Male circumcision and its relationship to HIV infection in South Africa: results of a national survey in 2002  . S Afr Med J. 2008; 98: 789-794.
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  75. ↑   Lima, V., mit: Anema A., Wood R., et al.: The combined impact of male circumcision, condom use and HAART coverage on the HIV-1 epidemic in South Africa: a mathematical model, Cape Town. (2009) 5th IAS Conference on HIV Treatment, Pathogenesis and Prevention (abstract WECA105).
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  77. ↑   DHS Comparative Reports 22, Beitrag: Levels and spread of HIV seroprevalence and associated factors: Evidence from national household surveys, Measre DHS. Abgerufen 29. September 2019.
  78. ↑   Brewer DD, Potterat JJ, Roberts Jr JM, Brody S. Male and Female Circumcision Associated With Prevalent HIV Infection in Virgins and Adolescents in Kenya, Lesotho, and Tanzania  . Annals of Epidemiology. 17(3): 217.e1-217.e12. Abgerufen am 2. Juni 2011.
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  81. ↑   Gisselquist D, Potterat JJ, Brody S. Running on empty: sexual co-factors are insufficient to fuel Africa's turbocharged HIV epidemic  . Int J STD AIDS. 2004; 15(7): 442-52.
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  83. ↑   Van Howe RS, Boyle GJ. Meta-analysis of HIV-acquisition studies incomplete and unstable. BJU Int. 31. Oktober 2018; Abgerufen am 5. September 2020.
    Zitat: Given the effectiveness of condoms, the lack of consistent findings on national levels, the methodologically flawed RCTs, the lack of translational research, and the impressive potential uptake and effectiveness of pre-exposure prophylaxis, circumcision as an intervention to prevent HIV infection should be treated with greater scepticism.
  84. ↑ a b   Denniston, George C.: World Health Organization, HIV, and male circumcision, Doctors Opposing Circumcision. (29. Juni 2020). Abgerufen 2. September 2020.
  85. ↑   Fish, Max, Shavisi, Arianne, Gwaambuka, Tatenda, Tangwa, Godfrey B., Ncayiyana, Daniel, Earp, Brian D. A new Tuskegee? Unethical human experimentation and Western neocolonialism in the mass circumcision of African men. Developing World Bioeth. 9. September 2020; 00: 1-16. PMID. Abgerufen am 7. April 2021.
  86. ↑   Mayan, Madhur, Hamilton, Robert J., Juurlink, David N., Austin, Peter C., Jarvi, Keith A.. Circumcision and Risk of HIV Among Males From Ontario, Canada. J Urol. 23. September 2021; PMID. DOI. Abgerufen am 2. Oktober 2021.
    Zitat: We found that circumcision was not independently associated with the risk of acquiring HIV among men from Ontario, Canada.
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