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Anatomical investigations have identified the prepuce as a primary erogenous zone in humans.<ref name="ErogenousZones">{{REFjournal
Anatomical investigations have identified the prepuce as a primary erogenous zone in humans.<ref name="ErogenousZones">{{REFjournal
  |last=Winkelmann
  |last=Winkelmann
  |first=R.K.
  |init=RK
  |title="The Erogenous Zones: Their nerve supply and significance." Proceedings of the staff meetings of the Mayo Clinic.
  |title="The Erogenous Zones: Their nerve supply and significance." Proceedings of the staff meetings of the Mayo Clinic.
  |journal=
  |journal=
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For over a hundred years, anatomical research has confirmed that both the penile and clitoral prepuce (foreskin) are richly innervated, specific erogenous tissue with specialised encapsulated (corpuscular) sensory receptors, such as Meissner's corpuscles, Pacinian corpuscles, genital corpuscles, Krause end bulbs, Ruffini corpuscles, and mucocutaneous corpuscles. These receptors transmit sensations of fine touch, pressure, proprioception, and temperature.<ref name="Nervenendigungen">{{REFjournal
For over a hundred years, anatomical research has confirmed that both the penile and clitoral prepuce (foreskin) are richly innervated, specific erogenous tissue with specialised encapsulated (corpuscular) sensory receptors, such as Meissner's corpuscles, Pacinian corpuscles, genital corpuscles, Krause end bulbs, Ruffini corpuscles, and mucocutaneous corpuscles. These receptors transmit sensations of fine touch, pressure, proprioception, and temperature.<ref name="Nervenendigungen">{{REFjournal
  |last=Dogiel
  |last=Dogiel
  |first=A.S.
  |init=AS
  |title=Die Nervenendigungen in der Schleimhaut der äusseren Genitalorgane des Menschen
  |title=Die Nervenendigungen in der Schleimhaut der äusseren Genitalorgane des Menschen
  |trans-title=Nerve endings in a mucous membrane of external genital organs of the human
  |#trans-title=Nerve endings in a mucous membrane of external genital organs of the human
  |language=German
  |#language=German
  |journal=Archiv für Mikroskopische Anatomie
  |journal=Archiv für Mikroskopische Anatomie
  |volume=41
  |volume=41
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}}</ref><ref>{{REFjournal
}}</ref><ref>{{REFjournal
  |last=Dogiel
  |last=Dogiel
  |first=A.S.
  |init=AS
  |title=Über die Nervenendapparate in der Haut des Menschen
  |title=Über die Nervenendapparate in der Haut des Menschen
  |trans-title=About the nerve end apparatuses in the human skin
  |#trans-title=About the nerve end apparatuses in the human skin
  |language=German
  |#language=German
  |journal=Ztschr Wiss Zool
  |journal=Ztschr Wiss Zool
  |volume=75
  |volume=75
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}}</ref><ref name="Ohmori">{{REFjournal
}}</ref><ref name="Ohmori">{{REFjournal
  |last=Ohmori
  |last=Ohmori
  |first=D.
  |init=D
  |title=Über die Entwicklung der Innervation der Genitalapparate als peripheren Aufnahmeapperat der genitalen Reflexe
  |title=Über die Entwicklung der Innervation der Genitalapparate als peripheren Aufnahmeapperat der genitalen Reflexe
  |trans-title=About development of the innervation of the genital apparatuses as a peripheral recording device of the genital reflexes
  |#trans-title=About development of the innervation of the genital apparatuses as a peripheral recording device of the genital reflexes
  |language=German
  |#language=German
  |journal=Zeitschrift für Anatomie und Entwicklungsgeschichte
  |journal=Zeitschrift für Anatomie und Entwicklungsgeschichte
  |volume=70
  |volume=70
Zeile 70: Zeile 70:
}}</ref><ref>{{REFjournal
}}</ref><ref>{{REFjournal
  |last=Yamada
  |last=Yamada
  |first=K.
  |init=K
  |title=Studies in the innervation in tenth month human embryo.
  |title=Studies in the innervation in tenth month human embryo.
  |journal=Tohoku J Exper Med
  |journal=Tohoku J Exper Med
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}}</ref><ref>{{REFjournal
}}</ref><ref>{{REFjournal
  |last=Yamada
  |last=Yamada
  |first=K.
  |init=K
  |title=On the sensory nerve terminations in clitoris in human adult
  |title=On the sensory nerve terminations in clitoris in human adult
  |journal=Tohoku J Exper Med
  |journal=Tohoku J Exper Med
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}}</ref><ref name="CutaneousInnervation">{{REFjournal
}}</ref><ref name="CutaneousInnervation">{{REFjournal
  |last=Winkelmann
  |last=Winkelmann
  |first=R.K.
  |init=RK
  |title=The cutaneous innervation of human newborn prepuce
  |title=The cutaneous innervation of human newborn prepuce
  |journal=Journal of investigative dermatology
  |journal=Journal of investigative dermatology
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}}</ref><ref>{{REFjournal
}}</ref><ref>{{REFjournal
  |last=Winkelmann
  |last=Winkelmann
  |first=R.K.
  |init=RK
  |title=The mucocutaneous end-organ
  |title=The mucocutaneous end-organ
  |journal=Arch Dermatol
  |journal=Arch Dermatol
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}}</ref><ref>{{REFjournal
}}</ref><ref>{{REFjournal
  |last=Krantz
  |last=Krantz
  |first=K.E.
  |init=KE
  |title=Innervation of the human vulva and vagina: a microscopic study
  |title=Innervation of the human vulva and vagina: a microscopic study
  |journal=Obstet Gynecol
  |journal=Obstet Gynecol
Zeile 170: Zeile 170:
The Innervation of the foreskin is impressive <ref>{{REFjournal
The Innervation of the foreskin is impressive <ref>{{REFjournal
  |last=Moldwin
  |last=Moldwin
  |first=R.M.
  |init=RM
  |last2=Valderrama
  |last2=Valderrama
  |first2=E.
  |init2=E
  |title=Immunohistochemical analysis of nerve distribution patterns within preputial tissues
  |title=Immunohistochemical analysis of nerve distribution patterns within preputial tissues
  |journal=J Urol
  |journal=J Urol
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* Meissner's corpuscles,<ref name="Mucosa">{{REFjournal
* Meissner's corpuscles,<ref name="Mucosa">{{REFjournal
  |last=Taylor
  |last=Taylor
  |first=J.R.
  |init=JR
  |author-link=John R. Taylor
  |author-link=John R. Taylor
  |last2=Lockwood
  |last2=Lockwood
  |first2=A.P.
  |init2=AP
  |last3=Taylor
  |last3=Taylor
  |first3=A.J.
  |init3=AJ
  |title=The prepuce: Specialized mucosa of the penis and its loss to circumcision
  |title=The prepuce: Specialized mucosa of the penis and its loss to circumcision
  |journal=British Journal of Urology International
  |journal=British Journal of Urology International
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* free nerve endings, end bulbs of Krause,<ref name="Nervenendigungen"/><ref name="Depth">{{REFjournal
* free nerve endings, end bulbs of Krause,<ref name="Nervenendigungen"/><ref name="Depth">{{REFjournal
  |last=Bazett
  |last=Bazett
  |first=H.C.
  |init=HC
  |last2=McGlone
  |last2=McGlone
  |first2=B.
  |init2=B
  |last3=Williams
  |last3=Williams
  |first3=R.G.
  |init3=RG
  |last4=Lufkin
  |last4=Lufkin
  |first4=H.M.
  |init4=HM
  |title=Depth, distribution and probable identification in the prepuce of sensory end-organs concerned in sensations of temperature and touch; thermometric conductivity
  |title=Depth, distribution and probable identification in the prepuce of sensory end-organs concerned in sensations of temperature and touch; thermometric conductivity
  |journal=Archives of Neurology and psychiatry
  |journal=Archives of Neurology and psychiatry
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* genital and bulbs <ref>{{REFjournal
* genital and bulbs <ref>{{REFjournal
  |last=Halata
  |last=Halata
  |first=Z.
  |init=Z
  |last2=Munger
  |last2=Munger
  |first2=B.L.
  |init2=BL
  |title=The neuroanatomical basis for the protopathic sensibility og the human glans penis
  |title=The neuroanatomical basis for the protopathic sensibility og the human glans penis
  |journal=Brain Res
  |journal=Brain Res
Zeile 260: Zeile 260:
  |last=Cauna
  |last=Cauna
  |first=Nikolajs
  |first=Nikolajs
|init=N
|last2=Ross
  |first2=Leonard L.
  |first2=Leonard L.
  |last2=Ross
  |init2=LL
  |title=The fine structure of meissner's touch corpuscles of human fingers
  |title=The fine structure of meissner's touch corpuscles of human fingers
  |journal=Journal of Cell Biology
  |journal=Journal of Cell Biology
Zeile 300: Zeile 302:
}}</ref> They are concentrated in areas of the body denoted as erogenous zones, which include the foreskin, clitoris, lip and nipple.<ref name="ErogenousZones"/> J.R. Taylor (1996) noted their presence in the foreskin,<ref name="Mucosa"/> and C.J. Cold & Taylor (1999) reported "Most of the encapsulated receptors of the foreskin are Meissner corpuscles, as they contact the epithelial basement membrane."<ref>{{
}}</ref> They are concentrated in areas of the body denoted as erogenous zones, which include the foreskin, clitoris, lip and nipple.<ref name="ErogenousZones"/> J.R. Taylor (1996) noted their presence in the foreskin,<ref name="Mucosa"/> and C.J. Cold & Taylor (1999) reported "Most of the encapsulated receptors of the foreskin are Meissner corpuscles, as they contact the epithelial basement membrane."<ref>{{
REFjournal
REFjournal
|first=C.J.
  |last=Cold
  |last=Cold
  |first2=J.R.
  |init=CJ
  |last2=Taylor
  |last2=Taylor
|init2=JR
  |title=The prepuce
  |title=The prepuce
  |journal=British Journal of Urology International
  |journal=British Journal of Urology International
Zeile 313: Zeile 315:
}}</ref> Early observations were noted by A.S. Dogiel (1893),<ref name="Nervenendigungen"/> D. Ohmori (1924),<ref name="Ohmori"/> and H. C. Bazett (1935),<ref>{{REFjournal
}}</ref> Early observations were noted by A.S. Dogiel (1893),<ref name="Nervenendigungen"/> D. Ohmori (1924),<ref name="Ohmori"/> and H. C. Bazett (1935),<ref>{{REFjournal
  |last=Bazett
  |last=Bazett
  |first=H.C.
  |init=HC
  |title=Methods of investigation of sensation in man and the theoretical value of the results obtained
  |title=Methods of investigation of sensation in man and the theoretical value of the results obtained
  |journal=Proc. A. Research Nerv. & Ment. Dis.
  |journal=Proc. A. Research Nerv. & Ment. Dis.
Zeile 353: Zeile 355:


The foreskin has important sexual nerve receptors that are removed during circumcision.<ref name="CutaneousInnervation"/><ref name="ErogenousZones"/><ref name="Mucosa"/><ref>{{REFjournal
The foreskin has important sexual nerve receptors that are removed during circumcision.<ref name="CutaneousInnervation"/><ref name="ErogenousZones"/><ref name="Mucosa"/><ref>{{REFjournal
|first=C.J.
  |last=Cold
  |last=Cold
  |first2=J.R.
  |init=CJ
  |last2=Taylor
  |last2=Taylor
|init2=JR
  |title=The prepuce
  |title=The prepuce
  |journal=British Journal of Urology International
  |journal=British Journal of Urology International
Zeile 365: Zeile 367:
  |pubmedID=10349413
  |pubmedID=10349413
}}</ref> Circumcision removes the most sensitive part of a man's penis. The five most sensitive areas of the penis are on the foreskin. The transitional region from the external to the internal foreskin is the most sensitive region of the fully intact penis, and more sensitive than the most sensitive region of the circumcised penis.<ref name="FineTouchPressure">{{REFjournal
}}</ref> Circumcision removes the most sensitive part of a man's penis. The five most sensitive areas of the penis are on the foreskin. The transitional region from the external to the internal foreskin is the most sensitive region of the fully intact penis, and more sensitive than the most sensitive region of the circumcised penis.<ref name="FineTouchPressure">{{REFjournal
|last=Sorrells
  |first=Morris L.
  |first=Morris L.
  |last=Sorrells
  |init=ML
|last2=Snyder
  |first2=James L.
  |first2=James L.
  |last2=Snyder
  |init2=JL
  |title=Fine-touch pressure thresholds in the adult penis
  |title=Fine-touch pressure thresholds in the adult penis
  |journal=BJU International
  |journal=BJU International
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